Familial blood vessel tumors and subsequent cancers

Outcome of Subsequent Pregnancies in Familial Molar Pregnancy

Familial gastrointestinal carcinoid tumours and associated cancers.

BACKGROUND Carcinoid tumours are neuroendocrine neoplasms mainly located in the gastrointestinal tract and bronchopulmonary system. Our study's aim was to characterise the familial nature of gastrointestinal carcinoid tumours using the Swedish Family-Cancer Database, which includes >11.5 million individuals. METHODS Familial relative risks (RRs) of carcinoid tumours were estimated for individ...

Epigenetic alterations in sporadic and familial cancers

10 INTRODUCTION 12 REVIEW OF THE LITERATURE 13 1 Epigenetics overview 13 1.1 DNA methylation 14 1.2 Post-translational histone modifications and chromatin remodeling 16 1.3 Noncoding RNAs and RNA interference 17 1.4 Interplay between different epigenetic factors 18 1.5 Epigenetic inheritance 19 2 Basic characteristics of cancer 20 3 Cancer genetics 23 3.1 Tumor suppressor genes 23 3.2 Oncogenes...

Familial clusters of ANCA small-vessel vasculitis

Small-vessel vasculitides associated with the presence of antineutrophil cytoplasmic antibodies in the serum are characterized by inflammation and necrosis of small vessels. A pauci-immune necrotizing crescentic glomerulonephritis typically occurs when there is renal damage. Pathogenesis of these diseases remains unclear although infectious, genetic and environmental factors have been involved....

Ecosinoids and Blood Vessel Structure

Ecosinoids and blood vessel structure We should, perhaps, pay more attention to the influence that ecosinoids have on blood vessel behavior and structure, as substances such as nonsteroidal antiinflammatory drugs (NSAIDs) and the so called selective cyclooxygenase 2 inhibitors are extensively employed by the population at large. In this issue of Vascular Health and Risk Management, Claridge and...